vanderbilt molecular pathogenesis

Our laboratory investigates the structural basis for recognition, biochemical function and biological specificity of proteins and nucleic acids. Resources. Brian O. Bachmann, Ph.D. The goal of this study is to identify genes that convey susceptibility to congenital diaphragmatic hernia in humans. Vanderbilt researchers are at the forefront of a golden age in biomedical science . Issues with this site? This research was supported by the National Institutes of Health (grants AI118932, CA116087, AI039657, AI112541) and the Department of Veterans Affairs. The findings provide new insights into the sources of energy used by this complex molecular machine linked to the pathogenesis of gastric cancer. Immunogold labeling studies confirmed that Cag3 is a peripheral component of the complex. The goal of this study is to identify genes that convey susceptibility to congenital diaphragmatic hernia in humans. (2)Division of Pediatric Urology, Department of Urology, Vanderbilt University Medical Center, Nashville, TN … JavaScript is disabled for your browser. Incomplete complexes formed by Δcag3 or ΔcagT mutants retained the 19-nm-diameter ring but lack an organized outer ring. Director, Vanderbilt Institute for Infection, Immunology & Inflammation. Vice Chair for Research, Department of Pathology, Microbiology, and Immunology Factors and processes involved in the battle for metal between bacterial pathogens and their hosts Bacterial type IV secretion systems (T4SSs) can function to export or import DNA, and can deliver effector proteins into a wide range of target cells. Specifically, we seek to define the bacterial virulence mechanisms and host defenses employed during osteomyelitis, an invasive infection … in Biology from Bangalore University, India and his Ph.D. in Functional Genomics from the University of Heidelberg, Germany. The Lamb Center for Pediatric Research is an interdisciplinary research unit combining interests in infectious diseases, microbiology, and immunology. We employ a diverse set of approaches to study pathogenesis, but a focus involves structural studies of relevant pathogen or host proteins. Postdoctoral Research - Vanderbilt University Medical Center. As Co-PI of the Vanderbilt Center for Undiagnosed Diseases (VCUD), I provide oversight of the entire VCUD and development and implementation of all policies, procedures and processes including compliance with institutional, UDN and NIH policies. Purpose. The identification of such genes, and examination of their structure and function, will enable a delineation of molecular pathogenesis and, ultimately, prevention or treatment of congenital diaphragmatic hernia. pylori cag T4SS that are optimized for function in the human gastric mucosal environment. Explore scientific resources, protocols and other pages. Mechanisms of Bacterial Pathogenesis and Host Response Pathogenic bacteria have evolved a diverse array of mechanisms for delivering toxins and other virulence factors into the interior of host cells. He earned his M.S. Previous studies established that uropathogenic E. coli - the primary cause of urinary tract infections (UTIs) - can adhere to vaginal epithelial cells preceding UTI. Gifts to the Libraries support the learning and research needs of the entire Vanderbilt community. Airway epithelial cells are prone to assault by risk factors and are considered to be the primary cell type involved in the field of cancerization. Some features of this site may not work without it. The molecular determinants of lung cancer risk remain largely unknown. Interested parties should send a cover letter and CV to benjamin.spiller@vanderbilt.edu The Vanderbilt Institute of Chemical Biology, 896 Preston Building, Nashville, TN 37232-6304, phone 866.303 VICB (8422), fax 615 936 3884 Vanderbilt University is committed to principles of equal opportunity and affirmative action. By type. The Center, established in 1990 through the generous support of Mr. and Mrs. George C. Lamb, Jr., is dedicated to basic research in the molecular pathogenesis of pediatric infectious diseases. EOE/AA/Women/Minority/Vets/Disabled, Department of Pathology, Microbiology and Immunology, About the Division of Molecular Pathogenesis, Pathology, Microbiology and Immunology Faculty. Professor, Departments of Chemistry and Biochemistry VICB Associate Director, Molecular Discovery Director, Vanderbilt Chemistry … [CDATA[/* > Find Your Major > Molecular and Cellular Biology. Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches. The Vanderbilt Center for Mucosal Inflammation and Cancer Seminar Series Keith T. Wilson, M.D. pylori proteins, CagM, CagT, Cag3, CagX, and CagY, each of which is required for cag T4SS activity. The major focus of my research is to understand the interaction between host and pathogen during invasive bacterial infections. Our goal is to advance and disseminate long-lasting resources, discoveries, curricula, cures, and diagnostics on the microbiome. Negative stain single-particle electron microscopy revealed complexes 41 nm in diameter, characterized by a 19-nm-diameter central ring linked to an outer ring by spoke-like linkers. Molecular pathways involved in H. pylori-induced apoptosis in epithelial cells, T cells, and macrophages are being dissected. Division of Allergy, Pulmonary and Critical Care Medicine T-1217 MCN 1161 21st Ave. S. Nashville, TN 37272-2650 Stahlman Chair in Infectious Diseases and Inflammation, Immunometabolism & Metabolic Diseases, Tumor Biology & Tumor Immunology, Human immunology, genetics, T cells, innate immunity, flow and mass cytometry, host-microbe interactions, microbiome, bioinformatics, GI pathology, epigenetic reprogramming, pancreatic cancer, Professor of Pathology, Microbiology & Immunology, DNA replication, mutagenesis, and evolution, Innate immunity initiated by activation of Toll-Like Receptor 3, next generation sequencing applications, pathogenesis of intracellular microbes, Immune regulation in autoimmunity and transplantation, Regulation of cell proliferation by growth factors, oncogenes, growth inhibitors and tumor suppressor genes, Estrogen, testosterone, sex hormones, T cells, innate lymphoid cells, asthma, allergy, Innate immune responses to bacterial pathogens in the lung, Mucosal immunology, IEL, iCD8alpha, osteopontin, granzyme, Pierre Soupart Chair in Obstetrics and Gynecology, Reproductive medicine, human endometium, endometrial dysfunction, endometriosis, progesterone action, Pathogenesis, helicobacter pylori, gastric cancer, carcinogenesis, infectious disease, bacterial pathogenesis, inflammation, malignancy, Molecular investigations of familial disorders, Lung, miRNA, exRNA (extracellular RNA), extracellular vesicles, allergy, asthma, Th2, Professor of Molecular Physiology & Biophysics, Cornelius Vanderbilt Chair in Immunobiology, T cell metabolism in inflammation and anti-tumor immunity, Amphibian immune defenses against an ancient fungal pathogen, Chair of the Department of Pathology, Microbiology and Immunology, Dorothy Beryl and Theodore R. Austin Chair in Pathology, Structure and biology of integrin adhesive receptors for extracellular matrix proteins, Clinical Microbiology, Molecular Diagnostics, Opportunistic pathogens, Microbe-microbe interactions, Personalized microbiology, Urinary tract infections, Jeffrey W. Mast Chair in Orthopaedics Trauma and Hip Surgery, The role of coagulation in normal and pathologic orthopaedic related wounds, Chair of the Department of Orthopaedic Surgery and Rehabilitation, Professor of Orthopaedic Surgery and Rehabilitation, Rehabilitation Dan Spengler, M.D., Chair in Orthopaedics, Proteomics of sarcomas, bone metastasis and tissue engineering, Assistant Professor of Medicine, Infectious Disease, Understanding host defense in pre-existing inflammatory conditions, Corneilius Vanderbilt Chair in Anesthesiology, Mechanisms of sepsis-induced systemic inflammation and organ injury with emphasis on the roles of natural killer (NK) and T lymphocytes, Director, Vanderbilt Institute for Infection, Immunology & Inflammation, Director, Division of Molecular Pathogenesis, Vice Chair for Research, Department of Pathology, Microbiology, and Immunology, Factors and processes involved in the battle for metal between bacterial pathogens and their hosts, Research Instructor Department of Pathology, Microbiology, and Immunology, Genomics, molecular biology, genetics and biochemistry of HIV-1 infection, Structural Biology of virulence factors, host-pathogen relationship, and cytoskeletal regulation, Director, CALDx - Center for Advanced Lab Diagnostics, Cancer, breast cancer, genomics, ChIP-seq, RNAseq, mutations, chromatin, transcription, epigenetics, Lipoprotein assembly, lipid droplet formation, adipocyte biology, Mechanisms that regulate immune tolerance and why they fail in autoimmune disorders such at type 1 diabetes, Role of innate-type regulatory lymphocytes in health and chronic inflammatory diseases, Research Associate Professor of Pathology, Microbiology and Immunology, Regulation of blood coagulation proteolytic enzymes, Translational research in acute lung injury and lung transplantation, Professor of Cell & Developmental Biology, Cancer invasion, membrane trafficking, cytoskeleton, systems biology, secreted exosomes, extracellular RNA, Molecular and immunologic mechanisms of thyroid cancer invasion and metastasis, Host immune response to the gastric pathogen Helicobacter pylori, Interactions between the immune and metabolic systems, whole body metabolism, Resilience mechanism of gut commensals, metabolic targeting of gut microbes to promote commensal resilience, and the roles of bacterial toxin in promoting colorectal cancer development, Associate Professor of Medicine, Hematology/Oncology, Associate Professor of Cell and Developmental Biology, Mechanisms by which normal and malignant cells regulate programed cell death or apoptosis following DNA damage, Copyright © 2020 My current research interests are molecular investigations of the pathogenesis and treatment of Mendelian disorders. thyroid cancer, thyroid follicular neoplasms, molecular diagnostics, molecular pathogenesis, cancer diagnostics, tumor micro-environment, tumor immunology ... Vanderbilt University is committed to principles of equal opportunity and affirmative action. Learn more about giving to the Libraries. Seesandra V. Rajagopala, Ph.D., Associate Professor of Medicine Dr. Rajagopala is an Assistant Professor in the Department of Medicine at the Vanderbilt University Medical Center. The molecular biology and immunopathogenesis of chronic inflammatory states, particularly sarcoidosis. Director, Institute for Infection, Immunology and Inflammation (VI4) Director, Division of Molecular Pathogenesis, Ernest W. Goodpasture Chair in Pathology, https://etd.library.vanderbilt.edu/etd-03242017-091315. Research Description I am interested in exploring the etiology as well as pathogenesis of chronic inflammatory states, particularly sarcoidosis. Audrey Thomas Molecular Pathogenesis Research Assisstant at Vanderbilt University Medical Center Nashville, Tennessee 375 connections He continued his formal training by completing a Postdoctoral Fellowship in Prokaryotic Systems Biology with an emphasis on protein interaction networks at The Institute for Geno… Postdoc at Vanderbilt University Medical Center Nashville, Tennessee, ... working on understanding the molecular pathogenesis of the food-borne pathogen Campylobacter jejuni. Author information: (1)Division of Molecular Pathogenesis, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. More. Director, Vanderbilt Institute for Infection, Immunology, and Inflammation (VI4) Ernest W. Goodpasture Professor Vice Chair for Basic Research Chief, Division of Molecular Pathogenesis Vanderbilt University Medical Center. Welcome. Neurodegeneration. A unique training program available to graduate students and postdoctoral fellows in the Biomedical Sciences at Vanderbilt University allowing for integration of thesis work with important clinical, disease-based areas. Host-associated reservoirs account for the majority of recurrent and oftentimes recalcitrant infections. The cag T4SS core complex has an overall diameter and structural organization that differ considerably from the corresponding features of conjugative T4SSs. Molecular and Cellular Biology. Specifically, we study systems involved in bacterial pathogenesis, cell signaling, and cancer at the molecular level. Director, Division of Molecular Pathogenesis. Chair in Medicine, Mechanisms of bacterial immune evasion in the female reproductive tract, Assistant Professor of Pathology, Microbiology and Immunology, Post-transcriptional gene regulation in innate immunity and cellular stress, Functional genomic and epigenetic approaches to understanding gene regulation, Assistant Professor of Pathology, Microbiology and Immunology Division of Microbial Pathogenesis, Translational cancer research focused on molecular therapeutics, onco-immunology & bioinformatics, Professor of Pharmacology, Medicine, Pediatrics, and Pathology, Microbiology & Immunology, Director, Office of Medical Student Research, Mechanisms by which growth factors mediate and influence organ formation during embryogenesis, Assistant Professor of Medicine, Genetics, Assistant Professor of Pathology, Microbiology, and Immunology, Human immunology, human genetics, infectious diseases, molecular biology, primary immunodeficiencies (PID), immunogenetics, Associate Professor of Cell & Developmental Biology, Translational research in acute lung injury and sepsis focusing on molecular mechanisms, Research Instructor in Pathology, Microbiology and Immunology, Cellular differentiation, mechanisms and signals of stem cells, Assistant Professor of Biological Sciences, Microbiology, Genomics, Evolution, Population Genetics, Immunomodulatory therapies for the prevention of infection and sepsis following a severe burn injury, Assistant Professor of Medicine Division of Rheumatology & Immunology, B cell, T cell, autoimmunity, type 1 diabetes, arthritis, microbiome, Signal transduction, transcription regulation mechanisms, Centennial Professor of Biological Sciences, Associate Director, Institute for Infection, Immunology and Inflammation, Director, Vanderbilt Microbiome Initiative, Symbiosis, Microbiome, Virology, Evolution, Genomics, Origin of Species, Clinical dermatology, dermatopathology, cutaneous neoplasms, Linking gut microbiota, host metabolism, and disease, Assistant Professor of Biomedical Engineering, Interaction between host and pathogen during invasive bacterial infections, Research Assistant Professor of Pathology, Microbiology and Immunology, Immune response, cellular metabolism & tumor progression, Bacteria-host interactions, bacterial toxins, helicobacter pylori, and gastric cancer, Director, Division of Rheumatology & Immunology, Innate and acquired immunity in inflammatory arthritis, myositis, scleroderma, fibromyalgia, pain, Human B cell and antibody responses to infections, Replication, cell biology, and pathogenesis of coronaviruses; emerging viruses in biodefense, Investigating the role of Factor XI in coagulation and thrombosis, Molecular biolody and immunopathogenesis of chronic inflammatory states, particularly sarcoidosis, Research Assistant Professor, Department of Pathology, Microbiology and Immunology, Structure and function of large clostridial cytotoxins, Mechanisms regulating intestinal immunity, AIDS, HIV, pharmacogenomics, tuberculosis, Bacterial Signal Transduction and Multicellular Behavior in Uropathogens, Growth factor and cytokine receptors on T lymphocytes, The structure and function of type IV collagen, the major constituent of basement membranes, Interaction of EGFR and Notch signaling in the pathogenesis of premalignant gastric lesions and sex differences in EGFR signaling, Medical Director of the Microbiology Laboratory, Antimicrobial resistance, Bacterial pathogenesis, Diagnostic testing, Clinical microbiology, Cancer, precision medicine, computational biology, machine learning, cell signaling, chemical biology, single cell tools, Atherosclerosis, lipid, cholesterol, macrophage, Histopathology and immunopathology of pediatric viral pneumonias, etiology and pathogenesis of idiopathic interstitial lung diseases, cytologic diagnosis of disease, Dorothy B. and Theodore R. Austin Chair in Pathology, Antigen presentation and recognition by immune cells, Cellular immune responses directed against viral and bacterial pathogens; therapeutic immunization, HIV vaccines, Oncogenic Viruses, RNA-based mechanisms of antiviral and antitumor immunity, epigenomics, CRISPR screens, Neutralization of the Clostridium difficile toxins by antibodies and small molecule inhibitors, Structures and molecular mechanisms of bacterial toxins, Signaling pathways involved in mammary gland homeostasis and breast cancer, Functional genomics and systems biology analysis of the immune response and translation, Immunological mechanisms of autoimmunity in atherosclerosis, Major E.B. Organized outer ring Mendelian disorders to advance and disseminate long-lasting resources,,..., Ph.D Medical Center Nashville, TN 37235-1634 advance and disseminate long-lasting resources, discoveries, curricula cures... 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